Abstract

ANTIATHEROSCLEROTIC EFFECT OF POLICOSANOL ON HISTOPATHOLOGY OF CHOLESTEROL INDUCED MALE ALBINO RABBITS.

Purohit A, Kotru B* and Joshi K

Abstract

The rabbits were first made exogenously hyperlipidemic by giving them high fat diet and cholesterol powder (500mg/kg body weight) in 5ml of coconut oil orally for 15 days and then were administered with policosanol and is compared with the standard drug currently used in the market i.e statin. Hyperlipidemic control group is provided with cholesterol for complete 60 days and the result of plaque size is maximum (16.93% of total wall area) and that of lumen size is reduced upto minimum (28.96% of total wall area). While on the administration of policosanol the plaque size is reduced upto minimum of (8.26% of total wall area) and the lumen area is increased upto (35.45% of total wall area), which was concordant with statin that had showed the plaque size reduced upto (8.17% of total wall area) and increase of lumen area of about (48.93% of total wall area). The variation of body and organ weight was also studied and a non significant changes were observed in them. A slight significant variation were observed in case of organ weight of liver and aorta. Indicating that weight of individual is independent by its cholesterol intake and is widely dependent on the metabolic activity of the body organs. Thus a definite regression of atheroma and hindered plaque formation in aorta after policosanol treatment concluded that it possesses antiatherosclerotic potential in cholesterol induced male albino rabbits.

Keywords: Antiatherosclerotic potential, Saccharum officinarum, plaque, lumen, policosanol.