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Abstract

APPROACHES OF DRUG-EXCIPIENTS INTERACTION IN PHARMACEUTICAL DRUG PRODUCT FORMULATION

Shiva Kant Thakur*, Rahul Pal, Prachi Pandey, Arun Singh, Arsh Chanana, Ravindra Pal Singh

Abstract

Drug excipients interaction is essential for the formulation of the formulation of the pharmaceutical product which work as the preformulating factor of formulation. Excipients are the general term used to describe these non-therapeutic compounds. Excipients can interact with the active ingredient or with other substances in the environment; they are not inert substances/ingredients added to drugs to aid in production, administration, or absorption. As a result, a number of analytical techniques can be used to analyses the interaction between a drug and excipients, consisting thermal methods like TG, DTA, DSC, Thermomicroscopy, optical microscopy, XRD, IR, NMR, isothermal stress testing, isothermal microcalorimetry, isothermal titration calorimetry, high sensitivity DSC, and chromatography. Another more techniques although many analytical methods can be applied for detection working as hyphenated techniques like DSC-GC, DSC–FTIR are more advance methods. This Review discussed the basic drug-excipients interaction, Understanding the chemical and physical nature of excipients, different kinds of existing excipients, the classification systems in which we will be reviewed also however, here mainly named as including chemical, physical, and biopharmaceutical will be defined and subclassified accordingly. The three primary types of physical interactions are complexation, adsorption, and solid dispersions. Hydrolysis, oxidation, the Maillard process, isomerization, and polymerization are the most common chemical reactions, and Biopharmaceutical interactions occur after drug administration and mainly affect the pharmacokinetics of the drugs. The study of drug-excipients analyzed by the involving the different analytical methods like thermal methods, Chromatography and FTIR.

Keywords: Pharmaceutical Drug-Excipients, Drug excipient Interaction, Drug- excipient incompatibility, Advance Techniques.


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