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Abstract

TO THE DETAIL STUDY OF PHARMACOVIGILANCE RELATED DRUG LEVOCETRIZINE

Nehe Akshay Arjun*, Musale Yogesh Jagannath, Gore Shankar Datta, Nagare Bhakti Suhas and Shende Sangita Bhausaheb

Abstract

Pharmacovigilance is an important and integral part of clinical research relating to the detection, assessment, understanding and prevention of adverse effects, particularly long term and short term adverse effects of medicines. Adverse drug reaction means all the noxious and unintended responses that occur after the administration of the drug at any dose in patients which may be related to the drug. The science and activities used for systematically identifying and correlating drugs and side-effects and taking corrective actions fall under the discipline of Pharmacovigilance. Its main aim is to minimize the risk related to drug use and to maximize their benefits. According to the regulations of worldwide health agencies, pharmacovigilance units collect adverse events from all over the world that were caused or might have been caused by the use of a specific drug. The aim of this review is to provide a summary of methods used in pharmacovigilance to guarantee the safety, drug, development and future need of pharmacovigilance in clinical practice Levocetirizine, the R-enantiomer of cetirizine dihydrochloride has pharmacodynamically and pharmacokinetically favourable characteristics, including rapid onset of action, high bioavailability, high affinity for and occupancy of the H1-receptor, limited distribution, minimal hepatic metabolism together with minimal untoward effects. Several well conducted randomized clinical trials have demonstrated the effectiveness of levocetirizine for the treatment of allergic rhinitis and chronic idiopathic urticaria in adults and children. In addition to the treatment for the immediate short-term manifestations of allergic disease, there appears to be a growing trend for the use of levocetirizine as long-term therapy. In addition to its being a potent antihistamine, levocetirizine has several documented anti-inflammatory effects that are observed at clinically relevant concentrations that may enhance its therapeutic benefit. This review will consider the potential or otherwise of the reported anti-inflammatory effects of levocetirizine to enhance its effectiveness in the treatment of allergic disease.

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