Abstract

A REVIEW ON: FLOATING DRUG DELIVERY SYSTEM

Vinod Sarpa Vasave*

Abstract

Floating drug delivery systems (FDDS) have a lower bulk density than gastric fluids, consequently they float in the stomach for longer decades of time without altering the gastric emptying rate. The medicine is released gradually and at a controlled pace from the system while it is floating on the stomach contents. The residual approach in the stomach is emptied once the medicine is released. As a consequence, the Gastric Residence Time (GRT) is enhanced, and differences in plasma drug concentration are better controlled. The system must have enough structure to formulate a cohesive gel barrier and disintegrate gradually enough to act as a drug reservoir while maintaining an overall specific gravity lower than that of stomach contents. The methodologies exploited in the growth of FDDS by formulating effervescent and non effervescent floating tablets based on buoyancy mechanism. By utilizing above viable approaches it is feasible to deliver drugs which have narrow therapeutic window. Our review article is in pursuit of giving comprehensive data on the pharmaceutical underpinnings of their design, classification, preparation determinants affecting on FDDS, advantages, applications, drawbacks and the future capability of FDDS.

Keywords: Gastro retentive system, Floating drug delivery system, Classification, Methods, Evaluation.