Abstract

TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS) AS A NOVEL TOOL FOR DRUG DELIVERY

Rahul Pal*, Prachi Pandey, Saman Waheed, Shiva Kant Thakur, Vidhi Sharma, Arsh Chanana and Ravindra Pal Singh

Abstract

A transdermal patch is generally defined as medicated adhesive patch which is placed on the top most layer of skin to deliver a specific amount of dose of particular medicine for the particular skin related disease through the skin and into the bloodstream after that show their therapeutic effect in given period of time. Allover 76% of drug can administer in oral route of administration, can’t give desired therapeutic effect, in case of drug considered under transdermal drug delivery system it can give systemic effect or therapeutic effect in given prolonged period of time and maintain its therapeutic activity as well as therapeutic window for particular disease treatment. Transdermal route has a number of advantages over conventional drug delivery routes such as avoidance of first pass effect, enhanced bioavailability, patient compliance, painless delivery of medicament, ease of application, removal of patch in case of toxicity occurring. Transdermal drug delivery system is a new advance recent novel technology which having the great future, patches discovery on the broader peak for their local action or topical action. The routes of drug absorption through the skin are mainly of intercellular, intracellular and trans appendageal considering. Transdermal patch consisting various components in their formulation such as backing membrane, drug reservoir, adhesive layer, release control membrane and liner. In this article providing lots information in the form of review article discussing firstly anatomy of skin which is the main organ responsible of their action on that particular site for the skin related diseases, transdermal patch mechanism involving, permeation enhancer especially for the promoting penetration of drugs into skin included in the formulation of patches, different types of patches formulation, evaluation parameters and recent techniques include in the article.

Keywords: Transdermal Drug delivery, Structure and Anatomy of skin, Permeation Enhancer, Formulation, Evaluation of TDDS Patches and Recent approaches.