Abstract

ANTHELMINTIC ACTIVITY OF THE LEAVES OF MURRAYA KOENIGII LINN AND MUSSAENDA FRONDOSA LINN.

Asha Kesari* and Dr. Bhim Charan Maiti

Abstract

The aim of the present study was to evaluate the anthelmintic potential of crude extracts of leaves of Murraya koenigii and Mussaenda frondosa in different fractions namely petroleum ether, chloroform and methanol using Pheretima posthuma (Annelida) as test worms. Various concentrations (2.5-20.0 mg /ml) of the different fractions were tested in the bioassay which involved determinations of the time of paralysis (P) and the time of death (D) of the worms. Albendazole (10.0mg / ml) solution was included as standard reference and Tween 80 (0.1%) as control .The result of the present study indicated that the petroleum ether, chloroform and methanolic fractions of Murraya koenigii and Mussaenda frondosa significantly demonstrated the slowing down of the movement and caused death of the worms at a concentration of 20.0mg /ml as compared to the standard reference, Albendazole. MFC fractions showed the minimum time required for death. In conclusion, the traditional use of the Murraya koenigii and Mussaenda frondosa as an anthelmintic has been confirmed and further studies are suggested to isolate the active principles responsible for the activity.

Keywords: Albendazole, Anthelmentic, Murraya koenigii, Mussaenda frondosa, Pheretima posthuma.