WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
Best Paper Award :
Dr. Dhrubo Jyoti Sen
Download Article: Click Here

Search

Track Your Article

Abstract

FORMULATION AND EVALUATION OF VILDAGLIPTIN – MORINGA OLEIFERA MICROBEADS

Krishnaveni Manubolu*, S. Laxmi Priyanka, K. Lavanya, S. Chandana and B. Prasanth

Abstract

Background: Natural gums and mucilages are being used due to their abundance in nature, safety and economy. The present investigation was an effort to study the suitability of gum obtained from Moringa oleifera as polymer in sustained release microspheres combination with another natural polymer sodium alginate. Gum is obtained from exudes of stem of Moringa oleifera. The gum is a polyuronide constituting of arabinose, galactose, and glucoronic acid in the ratio of 10:7:2, and rhamnose in traces. In this study gum isolated from trunk of Moringa oleifera was studied at different concentrations and conditions alone as well as in combination with sodium alginate. FTIR studies showed no evidence on interactions between drug and polymer. The percentage yield was decreased from F1-F6. This was found to be in the following order 89.65%, 86.56%, 85.91%, 85.62%, 84.10% and 83.25% respectively. The drug entrapment efficiency of the microparticles prepared from polymer blend was in the range 71.4% - 93.5%. The % drug release of F1 formulation at the end of 8th hour was found to be 75%. For F2, F3, F4, F5, F6 at the end of 8th hour 84%, 74%, 82.7%, 78.9%, 87.7%. and the percentage drug release of F1-F6 formulation at the end of 12th hour was found to be 97%, 96%, 82.8%, 100%, 91.8%, 93.6% was observed. The optimal sustained release effect was exhibited by F4 formulation. Aim of the study: To prepare and evaluate vildagliptin microbeads using moringa oleifera polymer which is a natural polymer. Methods: The microparticles containing Vildagliptin was prepared by ionotropic gelation method. Results: Various parameters like colour, odour, taste, solubility, sphere forming capacity and its stability were studied. The gum was found to be hygroscopic and organoleptically acceptable. The stability of spheres formed by Moringa gum alone and in combination with sodium alginate in different crosslinking agents was observed. The gum was found to form a spherical bead at 7% concentration. The stability of the microspheres formed from moringa gum was increased with the addition of sodium alginate in different concentrations. By increasing the concentration of sodium alginate with 7% moringa gum affected the size and shape of spheres. From the study it was concluded that Moringa gum and sodium alginate are biocompatible and can be effectively used as polymer in sustained release microspheres. Conclusion: after thorough study of the results obtained it was concluded that moringa oleifera can be used as carrier for preparation of microbeads. The drug release was varying form formulations to formulations it is due the particle size variation F4 exhibits 750μm which attributed to 12 hrs drug release and it exhibited 53.5 times swelling for optimum drug release. So, F4 is observed to exhibit optimized sustained effect.

Keywords: vildagliptin, moringa oleifera, natural polymer, controlled drug release.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More