Abstract

ENHANCEMENT OF SOLUBILITY AND DISSOLUTION OF ACETAZOLAMIDE BY SOLID DISPERSION

Shankrya M., Siddalinga Swamy P. M.*, Pradan P. Jain, Tejas K. R., A. M. T. Gurubasavaraj, C., M. D. Ruvayet Hussain, Madhuprakash H. A.

Abstract

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly water-soluble drugs. Solid dispersions of poorly water-soluble drugs with water-soluble carriers have been reduced the incidence of these problems and enhanced dissolution. Oral route is the most preferred route of drug delivery for most of the drugs but it presents a considerable challenge for water insoluble drugs. In the present work solid dispersions of Acetazolamide were prepared in order to improve the water solubility and there by its Bioavailabilty. The solid dispersions were prepared using Mannitol and PEG-6000 as the solubility enhancing agent. The solid dispersion was formulated as tablet and the disintegration and dissolution study were performed. The objective of this research was to improve the solubility and dissolution rate of Aceatazolamide by solid dispersion technique. The result revealed increased dissolution of Acetazolamide and improved bioavailability.

Keywords: Acetazolamide, Mannitol, PEG-6000, solid dispersion.