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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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	All	Since 2011
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Abstract

ETHANOLIC BRASSICA OLERACEAE ITALICA EXTRACT PRETREATMENT ALLEVIATES ISOPROTERENOL INDUCED OXIDATIVE MYOCARDIAL NECROSIS IN RATS

Gowri S*, Suganthi V, Dr.Gurusamy K

Abstract

Ethanolic Brassica oleraceae italica extract (200 mg/kg) pretreatment for 30 days in Isoproterenol (ISO) treated rats significantly decreased the levels of myocardial marker enzymes (lactate dehydrogenase, creatine kinase, Transaminases), uric acid and increased myocardial lipid peroxides. Histological examination of rat�s heart section confirmed myocardial injury with ISO administration and near normal pattern with ethanolic Brassica oleraceae italica extract pretreatment. The results of the present study for the first time provide clear evidence that the ethanolic Brassica oleraceae italica extract pretreatment enhances the antioxidant defense against ISO induced oxidative myocardial injury in rats and exhibit cardio protective property.

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