SYNTHESIS OF SOME MERCAPTO BENZOTHIAZOLE DERIVATIVE WITH THEIR CHARACTERIZATION AND BIOLOGICAL EVALUATION
Ashish Asrondkar*, Vrushali Patil, Neha Mishra, Anil S. Bobade and A. S. Chowdhary
Abstract
In present study we synthesized some 2-amino mercapto benzothiazole
and Acid Chloride derivatives and screen synthesized compounds for
their anti-microbial activity. 2-amino mercapto benzothiazole on
reacting with ethyl chloro acetate forms ester derivative of
benzothiazole which on further treatment of hydrazine hydrate formed
hydrazino derivatives of mercaptobenzothiazole, It was then treated
with carbon disulphide to form oxadiazole derivative of mercapto
benzothiazole and finally it was condensed with different substituted
Acid chloride to form final compound. Synthesized compounds have
been confirmed on the basis of spectral studies by using FT-IR, NMR,
Mass Spectrophotometer. All the compounds were screened for their in
vitro anti-inflammatory, in vitro anti oxidant and in vitro antibacterial
activity against E. coli, S. typhi, P. aeroginosa, Kleb pneumoniae, Vibrio chlorae.
Antifungal strain Candida albicans and Aspergillus niger using tube dilution method shows promising activity.
Keywords: 2-amino mercapto benzothiazole, anti-Inflammatory activity, antioxidant activity, and anti-microbial activity
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