Abstract

A NOVEL APPROACH-SELF EMULSIFYING DRUG DELIVERY SYSTEMS

Mamillapalli Udaya Sri*

Abstract

Self-emulsifying drug delivery systems are a crucial tool for managing medications with low bioavailability and water solubility. SEDDS contains chemicals with a lipid basis. It can assist with solubility and bioavailability problems in class II and IV medications biopharmaceutical classification systems. Depending on the manufacturing process, drugs that contain SEDDS can also be categorized as micro (Self-micro emulsifying drug delivery systems) and nano (Self-nano emulsifying drug delivery systems). Surfactants, co-surfactants, co-solvents, and an oil phase make up SEDDS. The identification of the pseudo-ternary phase diagram and selfemulsification process forms the foundation of preparation. The primary methods used to characterize SEDDS include the equilibrium phase diagram, turbidity measurement, droplet size, and zeta potential, as well as electronic microscopic investigations and nuclear magnetic resonance.

Keywords: Self-emulsifying drug delivery systems (SEDDS), Self-micro emulsifying drug delivery systems (SMEDDS), Self nano-emulsifying drug delivery systems (SNEDDS), Bioavailability, Co-surfactant, Co-solvents.