Abstract

SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME NOVEL PYRAZOLE DERIVATIVES

Lokesh Saini*, Ashok kumar Yadav, Priyanka Yadav, Dr. Sujeet Kumar Gupta, Shobhit Srivastava

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Abstract

In this current work I made an effort near make new Pyrazole analogue (5a-f) and evaluate them for anthelmintic activity. In the initial step substituted acetophenone(1a-f) was react with substituted phenyl hydrazines(2a-b) in Ethanol solution and glacial acetic acid was added as catalyst to form Substituted 2-phenyl-1-(1-phenyl ethylidene) hydrazine (3a-f) as intermediate. This intermediate was further reacted with Dimethyl formamide via Vilsmeir hack reagent, in the presence of sodium bicarbonate, to neutralize the reaction mixture and form substituted formyl pyrazole (4a-f). Further to get desired product substituted derivative (5a-f), it was reacted with 3-hydrazinyl quinolone in presence of ethanol as solvent. The final conformation was confirmed by 1HNMR and FTIR. Total value of FTIR, solubility, 1HNMR, and TLC are found to be recorded. The biological activity was performed as anthelmintic, compound (5a and 5e) has expressed maximum activity against standard drug Albendazole.

Keywords: Anthelmintic Activity, Albendazole, Pyrazole.