Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE DRUG DELIVERY SYSTEM OF ITRACONAZOLE

*Ishtiyaque Ahmed Mushtaque Ahmed, Dr. Amjad Khan Pathan and Shakeeb Akhtar Nehal Ahmad

Abstract

Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules and increase the residence time of the dosage form at the site of absorption. The drugs which have local action or those which have maximum absorption in gastrointestinal tract (GIT) require increased duration of stay in GIT. Itraconazole is an oral antifungal agent with a broad spectrum of activity. In the present research work different batches of itraconazole were prepared with two different polymers such as sodium alginate and guar gum. The tablets were prepared by direct compression methods and all tablets were subjected for different evaluation parameters Such as Hardness, Friability, Weight Variation, Thickness, Ex vivo mucoadhesion studies and in vitro drug release. The data obtained from the presents work it was clarified that desired drug release was not obtained. Varying composition of Chitosan from 100mg to 5mg and sodium alginate from 30mg to 10mg do not give satisfactory drug release. In formulation F10, 5mg Chitosan and 30 mg sodium alginate were used and only 54.99% drug release was obtained in 8 hrs. In case of guar gum as a mucoadhesive polymer same problem arises which is observed for formulation G8. Formulation G8 having 25mg guar gum and 5mg Chitosan gives only 52.45% drug release. This might be due to the poor solubility of drug. Hence it was concluded that to improve the solubility and bioavailability of the formulation, drug need to be converted into solid dispersion.

Keywords: Itraconazole, Mucoadhesive drug delivery systems, Chitosan, sodium alginate.