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Abstract

FORMULATION AND EVALUATION OF ROSA ALBA L EXTRACT LOADED PHYTOSOME

Harshit Mewada*, Rahim Khan, Dr. Brajesh Ku. Arjariya, Sheenam Mansuri, Mohd. Jalaluddin

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Abstract

These days, medicinal plants and their phytochemicals are a fantastic therapeutic choice for a wide range of illnesses. However, their clinical applicability may be constrained by poor selectivity and bioavailability. Consequently, phytosome technology is a cutting-edge strategy created by Indian researchers in an effort to address the problem of low bioavailability. Plants are referred to as phyto, and cells are referred to as some. In order to create lipid compatible molecular complexes with improved absorption and bioavailability, this innovative formulation combines a standardised plant extract with phospholipids. The phosphatidyl moiety, which is the head of the bifunctional compound and is lipophilic in nature, and the choline moiety, which is the tail of the bifunctional compound and is hydrophilic in nature, are both chemical compounds. The phosphatidylcholine's choline moiety binds to the hydrophilic phytoconstituents, and the phosphatidyl part, which is lipid soluble, subsequently envelops the choline-bound complex. A phyto-phospholipid complex with improved lipid solubility is created as a result. Phytosome benefits include improved trapping effectiveness, efficient nutrient safety, and higher bioavailability. In phytosomes, phosphatidylchloride serves as a good drug loading capacity as well as a sustain. The current study sought to develop a phytosome using Rosa alba L. flower extract.

Keywords: Phytosome, Rosa Alba, Novel Preparation, Herbal.


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