Abstract

A SIMPLE, REPRODUCIBLE, ACCURATE AND EFFECTIVE METHOD DEVELOPED AND VALIDATED FOR THE QUANTITATION OF THE ANTIHISTAMINE TERFENADINE IN MARKETED FORMULATION

Chatrapal Vishwakarma*, Rahim khan, Dr. Brajesh Kumar Arjariya, Sheenam Mansuri, Mohd. Jalaluddin

Abstract

Modern pharmaceuticals intended for human consumption must adhere to strict criteria and rules laid down by the relevant authorities. Only by analytical monitoring of a product's quality can the efficacy and safety of medicines be guaranteed. Determining the concentration of medication ingredients in a commercial formulation requires both art and science. The techniques were refined through experimentation on the basis of a comprehensive literature review and verified through statistical sample settings. The offered methods entirely achieve the goal of this study work due to their simplicity, speed, reproducibility, and economy. The entire UV work was carried out using a water-based HPLC system and a Labindia UV/Vis double beam-double detector spectrophotometer (3000 plus). The entire UV work was carried out using a water-based HPLC system and a Labindia UV/Vis double beam-double detector spectrophotometer (3000 plus). The quantification of the antihistamine terfenadine in commercial formulations will be accomplished by developing and validating a straightforward, repeatable, precise, and efficient spectrophotometric method. Determining a straightforward approach for Spectrophotometric Estimation of Terfenadine in Marketed Formulation by Using Appropriate UV Method is the goal of the current work.

Keywords: Terfenadine, antihistamine, validation, quantitation.