Abstract

OBSERVATIONAL STUDY OF CILNIDIPINE IN PATIENTS WITH ACCELERATED HYPERTENSION

Swetha Ramesh*, Priyanka Patro, Sai Divya Duggi and V. Santhoshini

Abstract

Background: Hypertension is well established as a major risk factor for cardiovascular disease. Although there is undeniable evidence to support the beneficial effects of antihypertensive therapy on morbidity and mortality, adequate blood pressure management still remains suboptimal. Research into the treatment of hypertension has produced a multitude of drug classes with different efficacy profiles. One of the oldest groups of antihypertensives, the calcium channel blockers are a heterogeneous group of medication. Cilnidipine is a dihydropyridine calcium antagonist. It is indicated for the management of hypertension for end organ protection. Methods: To achieve this purpose, a conducted on 88 elderly hypertensive patients with CKD selected from RVM hospital into four groups. The first group (n=18) was treated with Cilnidipine (5mg/day), second group (n=28) was treated with Cilnidipine (5 mg/bid), Cilnidipine (10mg/day) and the fourth group (n=17) was treated with Cilnidipine (10 mg/bid). All patients were followed up for six months and reported the blood pressure, serum urea, serum creatinine level and Blood urea nitrogen before and after treat and end of the follow up period. Results: The results showed a significant reduction in blood pressure among patients. Cilnidipine 5mg bid and 10 mg od, shows the less adverse effects in addition to maintaining the Blood pressure. The results showed the systolic pressure and diastolic pressure with Heart rate with p

Keywords: Malnutrition, mid-upper arm circumference (MUAC), stunting. Wasting.