Abstract

DESIGN, SYNTHESIS AND CHARACTERIZATION OF NOVEL ISOXAZOLE-QUINAZOLINONE LINKED ANALOGUES AS AN ANTIMICROBIAL AGENT

*Dr. Komal R. Savaliya

Abstract

In present work, a series of novel isoxazole derivative, namely, 6,8- dibromo-3-[4-(5-substitutedphenyl-1,2-oxazol-3-yl)phenyl]-2- phenylquinazolin-4-one were synthesized from 6,8-dibromo-3-{4-[3- (substitutedphenyl)prop-2-enoyl]phenyl}-2-phenylquinazolin-4-one and hydroxylamine hydrochloride by using dioxane as a solvent and potassium hydroxide as a base in moderate to excellent Yields. The chemical structures of the synthesized compounds were established by IR and 1H-NMR. All the compounds prepared here in (2a–2j) were screened for their antibacterial and antifungal activity with two bacteria Staphylococcus aureus, Escherichia Coli and two fungal strains Aspergillus Niger, Saccharomyces. Over all evaluation of the synthesized compounds suggests that most of them were found to show moderate to excellence antibacterial and antifungal activity as compared to the standard drugs like Streptomycin and Fluconazole respectively.

Keywords: Quinazolin-4-One; Isoxazole; antibacterial; antifungal; Dioxane.