Abstract

EXPLORING THE ANTIMICROBIAL POTENTIAL OF ISATIN AND DERIVATIVES: A COMPREHENSIVE REVIEW

Ramesh Kumar*

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Abstract

Isatin (1H-Indole-2, 3-dione) is a small nitrogen containing heterocyclic chemical moiety. It possesses an indole scaffold substituted with carbonyl groups at 2nd and 3rd position. It is also known as oxindole. Isatin nucleus can be modified in several ways to serve as a precursor for a large number of pharmacologically active compounds. It is a compound of significant importance in medicinal chemistry. Upon exploration of literature, it is found that several of isatin derivatives have promising pharmacological activity viz. antimycobacterial, anti-inflammatory, herpes simplex virus inhibitor, antiviral, antimicrobial, anticancer and anticonvulsant activities. In recent years it have attracted a great attention not only as drug candidate but also as insecticides, fungicide etc. The purpose of this review is to provide an overview of synthetic method and a detailed antimicrobial profile of isatin and analogs.

Keywords: Isatin; Indole-2, 3-dione; Antimicrobial; Antibacterial; Antifungal.