Abstract

FORMULATION AND EVALUATION OF ZOLMITRIPTAN RAPIMELTS

Balagani Pavan Kumar* and Manubolu Sindhuri

Abstract

The purpose of this study was to prepare controlled release Zolmitriptan rapimelts. These rapimelts are in the form of Tablets which were prepared by direct compression. The HPMC K15M polymer is used to prepare minimatrices which further converted to micromatrices. Micromatrices were evaluated for different preformulation parameters, drug content, percentage yield, moisture content and drug release. Based on the drug content and drug release optimized formulation of HPMC is used to prepare rapimelts. The physicochemical compatibility of the drug with other excipients used in the formulations was studied by FTIR analysis. The results obtained showed no physicochemical incompatibility between the drug and other excipients used in the formulations. The prepared Tablets were evaluated for different parameters such as thickness, weight variation, hardness, friability, drug content, disintegration time, water absorption ratio, wetting time, dispersion time and wetting volume. The Tablets were also evaluated for in vitro drug release in 0.1N HCl for 24hrs in USP Type II dissolution apparatus. In order to determine the mode of release, the data was fitted into various kinetic models and the optimized formulations followed Krosmeyer peppas model and Higuchi model respectively and n values less than 0.5which indicates Fickian diffusion mechanism of drug release.

Keywords: Zolmitriptan, Micromatrices, Rapimelts, Controlled release, HPMC K15M.