FORMULATION AND EVALUATION OF ZOLMITRIPTAN RAPIMELTS
Balagani Pavan Kumar* and Manubolu Sindhuri
Abstract
The purpose of this study was to prepare controlled release
Zolmitriptan rapimelts. These rapimelts are in the form of Tablets
which were prepared by direct compression. The HPMC K15M
polymer is used to prepare minimatrices which further converted to
micromatrices. Micromatrices were evaluated for different
preformulation parameters, drug content, percentage yield, moisture
content and drug release. Based on the drug content and drug release
optimized formulation of HPMC is used to prepare rapimelts. The
physicochemical compatibility of the drug with other excipients used
in the formulations was studied by FTIR analysis. The results obtained
showed no physicochemical incompatibility between the drug and
other excipients used in the formulations. The prepared Tablets were
evaluated for different parameters such as thickness, weight variation, hardness, friability,
drug content, disintegration time, water absorption ratio, wetting time, dispersion time and
wetting volume. The Tablets were also evaluated for in vitro drug release in 0.1N HCl for
24hrs in USP Type II dissolution apparatus. In order to determine the mode of release, the
data was fitted into various kinetic models and the optimized formulations followed
Krosmeyer peppas model and Higuchi model respectively and n values less than 0.5which
indicates Fickian diffusion mechanism of drug release.
Keywords: Zolmitriptan, Micromatrices, Rapimelts, Controlled release, HPMC K15M.
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