Abstract

A REVIEW ON: TOXICITY STUDIES IN ANIMALS

Honey Haridas*, Prothibha Das, Kadeejath Azmeena S. A., Khairunnisa T. and Khaseera Farsana

Abstract

A toxicity study is the investigation of either short or long-term toxic effects of a drug or chemical on animals. Acute toxicity is the toxicity produced by a pharmaceutical when it is administered in one or more doses during a period not exceeding 24 hours. Repeated dose toxicity studies focuses on adverse effects occurring after administration of a single dose or multiple doses of a test sample per day during a period from 14 to 28 days. Chronic toxicity is the ability of the substance or mixture of substances to cause harmful effects over an extended period, usually upon repeated and continuous exposure. Mutagenicity study of gene mutation, which are the changes in DNA. Carcinogenicity is the study of mechanism of induction of tumours. Teratogenicity study is to investigate the potential of a test agent to cause foetal malformations, embryo-foetal death, foetal weight reduction, or adverse effects on maternal health.

Keywords: Toxicity: Acute Toxicity: Sub Acute Toxicity; Chronic Toxicity, Mutagenicity: Carcinogenicity: Teratogenicity.