Abstract

IN VIVO STUDY (WOUND HEALING ACTIVITY) OF THE EXTRACT FROM THE FRUITS OF ANANAS COMOSUS

G. Supriya Reddy, J. Shruthi Reddy, K. Anjana Saraswathy, K. Pravalika, M. Venkata Swamy* and Sneha Reddy Kuthuru

Abstract

The process of healing Involves 2 distinct processes: Regeneration when healing takes place by proliferation of parenchymal cells and usually results in complete restoration of the original tissues. Repair when the healing takes place by poliferation of connective tissue elements resulting in fibrosis and scaring. At times, both the processes take place simultaneously. An attempt was made by us to evaluate the wound healing properties of the fruit of Ananas comosus. In the present study methanol and aqueous extract were prepared from the fruit of Ananas comosus and its wound healing properties were studied invivo models in albino rats. Studies with all test extracts for its wound healing properties of both excised and incised wound showed significant activity when compared to the control and positive control. The histological data of excised wound had taken place by epithelialisation of the wound. These studies revealed that the excised wound has healed by neovascularisation followed by stimulation of fibroblast resulting in the synthesis of collagen. The incised wound has revealed that extracts of fruit of Ananas comosus not only stimulate the rate of cross linking as evidenced by increased tensile strength. On the whole the fact all extracts increases tensile strength along with epithelialisation the drug may be used in wide ranging wound healing processes which established a new dimension to therapeutic efficacy of all bark extracts in wound healing activity.

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