Abstract

EVALUATION OF NEUROPROTECTIVE EFFECT OF DIOSGENIN ON ROTENONE INDUCED PARKINSON IN MICE MODEL; AN ADJUVANT THERAPY FOR PARKINSONS DISEASE

Govindaraj C.*, Senthil Kumar K. K., Yogakrishnan S. and Navaneethakrishnan S.

Abstract

This study aims to evaluate the neuroprotective effect of diosgenin on rotenone induced Parkinson animal model by analyzing behavioral changes, estimation of catecholamine levels, various endogenous antioxidant enzymes levels and histopathological evaluation. In recent years there has been growing interest in alternative therapies, among that one of the leading choice is adjuvant therapy. Before administration of rotenone, group IV and V is diosgenin was administration to orally for a period of 7 days (200mg/kg). After administration of rotenone in mice for a period of 7 days (3mg/kg ip), the Parkinson’s diseases was confirmed by various behavioral studies. To find out its neuroprotective effect of various behavioral studies, biochemical estimations, neurotransmitter evaluations and histopathological studies have been performed. The results were promising like the behavioral studies the rota rod the diogenin and diosgenin with standard treated group the muscle grip strength (96±1.155, 110.7±1.764) was significantly increased compared to rotenone induced group(35±1.528). Treatment with diosgenin and diosgenin with standard results in regains the levels of endogenous antioxidant levels to normal values. Especially neuroprotective effect of diosgenin and diosgenin with standard was confirmed by histopathology. So this study concludes the neuroprotective effect of diosgenin.

Keywords: diosgenin, neuroprtective, rotenone, grip strength, antioxidant and adjuvant therapy.