Abstract

FORMULATION AND EVALUATION OF MODIFIED RELEASE TABLETS OF GLICLAZIDE

Dr. N. Naidu* and M. P. Aramesh

Abstract

Gliclazide Modified from once daily administration to 24hrs blood glucose control. Employing an innovative pharmaceutical form based on a hydrophilic matrix to deliver this short-acting sulfonylurea, gliclazide modified release is associated with an unsurpassed efficacy: acceptability ratio, with the potential additional advantages inherent in reduced dosage and once-daily administration. The Formulation of Gliclazide Modified Release tablets using polymers namely hydroxy propyl methyl cellulose and in different grades. All 6 formulations were evaluated for invitro drug release using HPLC up to 16hrs. The drug release pattern was compared with that of marketed formulation. Hence it was the optimized formulation for sustaining the release of Gliclazide. The present works concludes with Gliclazide Modified Release six as the best formulation for the sustained release of Gliclazide.

Keywords: Gliclazide Modified, Hydroxy propyl methyl cellulose.