FORMULATION AND EVALUATION OF NIOSOMES OF ACYCLOVIR
M. V. Jhansi Priya* and M. Yellappa
.
Abstract
Acyclovir niosomes were prepared by thin film hydration and ether
injection process with different ratios of (1:2:2, 1:4:2) drug and and
Span-80, span 20(Non-ionic surfactant) cholesterol. The niosomes
prepar ed were in the size range of 0.5-5 microns in the case of hand
shaking process and 0.5-2.5 microns in the case of Ether inject ion
process. The order of encapsulation efficiency increases when span-80
concentration was increased. In-vitro release stuy on niosomes
indicates 99.15% release for formulation prepared with cholesterol:
Span-80 (2:4) and it takes an extended period of 1 day and 12 h for
release.
Keywords: Gene, RAPD, antioxidants, antibacterial activity, Solanum nigrum, Fusarium.
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