Abstract

FORMULATION AND EVALUATION OF ANTI ULCER SYRUP ON LEAVES OF Punica granatum (L)

Revathi M.*, Jignesh G., Karthick N., Prakash M., Karthikeyan. S. and Harish G.

Abstract

Peptic ulcer is a lesion of the gastric or duodenal mucosa occurs at a site where the mucosal epithelium is exposed to acid and pepsin.[1] Peptic ulcer is a chronic disease of multifactorial etiology. It is the most prevalent disease among the gastrointestinal tract diseases in most part of the world. Several plants and herbs are advocated for the treatment of gastrointestinal disorders including gastric ulcers. Many chemical compounds have been isolated from medicinal plants with antiulcer activity. Leaves of Punica granatum (L) have been reported to possess antiulcer property. The aim of the present research was to formulate and evaluate the antiulcer herbal syrup. The leaves of Punica granatum (L) powder was extracted by decoction method. The in-vitro anti-ulcer activity of decoction of leaves on Punica granatum (L) was evaluated by acid neutralizing capacity. From this study we conclude that decoction of leaves on Punica granatum (L) was significant reduction of ulcer at the dose of 500 mg/ml to be neutralize acid more significantly as compared to standard and acid neutralizing capacity was showed significant ANC50 ulcer at the dose of 75mg/ml. To prepare the leaves of Punica granatum (L) anti-ulcer syrup. Evaluated physicochemical parameters help to assess the quality of the formulation. Physicochemical parameters of Punica granatum (L) herbal syrup like orange colour, aromatic odour, sweet taste, pH 5.8, density 1.07gm, specific gravity 0.5289kg/m3 and viscosity 0.0582 poise.

Keywords: Punica granatum (L), Peptic ulcer, Decoction, Acid Neutralizing Capacity, Herbal Syrup.