Abstract

EVALUATION ON ANTIOXIDANT ACTIVITY OF CURRY LEAF EXTRACTS IN CISPLATIN INDUCED WISTAR RATS

Balasubramanian Sathyamurthy, Ganesh Dama, Arul Balasubramanian and Surya Narayana Vvs*

Abstract

Reactive oxygen species (ROS) are harmful molecules which are continuously produced and constantly attack or damage the molecules within cells. The process of oxygen species damage to the cells is referred to as oxidative stress. ROS cause cancer, aging and heart diseases. Glutathione, Lipid peroxides, superoxide dismutase, glutathione reductase and catalase play a very important role in removing free radicals. Cancers related to lungs, gastrointestinal tract, ovarian, bladder and testis are treated by cisplatin by damaging the tumors via apoptosis and also by the activation of various signal pathways. Curry leaves possess antioxidative, antimicrobial and cholesterol reducing activities are reported already in different studies. Our observation in animal model also shows curry leaves has significant antioxidant activity and therefore inclusion in our daily food is expected to protect the body from oxidative stress.

Keywords: Free Radicals, Curry Leaves, Antioxidant Enzymes, Cisplatin, Wistar Rats.