Abstract

FORMULATION AND EVALUATION OF ZALTOPROFEN NANOSUSPENSION BY QUASSI EMULSIFICATION SOLVENT DIFFUSION METHOD

Sunil J. Aher* and Swati Jagdale

Abstract

Present study was to prepare Zaltoprofen nanosuspension and characterization of the nanosuspension and the aim behind the nanosuspension as it increase the dissolution of the poorly soluble drug belong to the class II example Zaltoprofen was selected and found to increase in invitro dissolution and oral bioavailability of drug .It was prepare by Quassi Emulsification Solvent Diffusion method by using different ratio of drug: polymer: stabilizer .The formulation with a ratio of 1:1:0.5 (drug:polymer:stabilizer)show reduce particle size as well as more dissolution & drug entrapment. The formulations were analyzed for particle size using SEM, Zeta potential determination IR& DSC Studies, in vitro drug release studies. The particle size of the formulated nanosuspensions were found in the range of 248-355nm

Keywords: Nanosuspension, Eudragit RL100, Poloxamber407 Zaltoprofen, Quassi emulsification solvent diffusion.