Abstract

FEATURES AND FACTS OF GASTRO RETENTIVE FLOATING DRUG DELIVERY SYSTEMS-A REVIEW

Gudise Sita Mahalakshmi*, Chekuri Anusha, Brahmaiah Bonthagarala, M. Mohan Varma and K. S. Nataraj

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Abstract

Drugs with poor solubility and limited stability in intestinal fluids can be administered using floating drug delivery systems (FDDS), which were developed to keep the medicine in the stomach. The idea of FDDS is to create a dose form that will float on stomach fluids by making it less dense than those fluids. FDDS is a strategy for delivering medications that are unstable in the lower intestinal environment, have little solubility at higher pH levels, and are locally active with a small window of absorption in the upper gastrointestinal tract. The unique methodology in FDDS include methods for designing single- and multi-unit floating systems, methods for addressing physiological and formulation variability that affects stomach retention, and methods for utilising freshly created and produced polymers. FDDS are hydrodynamically regulated low-density systems with enough buoyancy to float over the contents of the stomach and remain buoyant there without slowing down the gastric emptying rate for a long time. Physiological and formulation variability impacting stomach retention, techniques to design single-unit and multiple-unit floating systems, and the utilisation of freshly produced and invented polymers are some examples of the unique methodology in FDDS. Floating dosage forms can be administered in traditional forms like tablets or capsules by including the gasgenerating agent and the proper components. This review also discusses several methods for creating floating dosage forms, as well as recent and innovative developments.

Keywords: Gastro retentive, floating drug delivery, low density, absorption window, buoyant.