Abstract

REVIEW ON SYNTHESIS OF DIBENZALACETONE FROM BENZALDEHYDE BY CLAISEN-SCHMIDT REACTION AND THEIR BIOLOGICAL ACTIVITIES

Jadhav Sanika D., Lokhande Rahul P.* and Hilal Nikita E.

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Abstract

Aldol condensation are essential to organic synthesis because they are able to produce carbon-carbon bonds. An enolate anion is formed starting aldol condensation, the enolate anion comes from an aldehyde or a ketone. Enolizable aldehydes and ketones undergo a reaction when either an acid or base catalyst is present. The product of the reaction gives α,β-unsaturated aldehyde or ketone. The reaction of an aldehyde with a ketone employing sodium hydroxide as the base is an example of a mixed aldol condensation reaction. Condensation of benzaldehyde with acetone in ethanolic alkaline solution leads to the formation of dibenzalacetone, which when treated with selected nucleophiles undergoes Michael addition to give a variety of heterocyclic compounds, these compounds have been characterized by physical method and also they have been screened for their anti bacterial activities. The dibenzalacetone exhibits a wide range of biological activities such as antifungal, antioxidant, antimalarial, analgesic and antitumor characteristics.

Keywords: Benzaldehyde, Dibenzalacetone, Claisen-Schmidt reaction, Biological Activities.