Abstract

FAST DISINTEGRATING TABLETS- A REVIEW

T. Anjali*, P. S. S. Prasanna Kumar, Srinivas Nandyala, V. Venkatalakshmi, D. Virginia, B. Tulasi Krishna, P. Tulasi Naga Durga, D. Lakshmi Sowmya and S. Durga Dinesh

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Abstract

Oral route is the most effective and safest route of drug delivery because of wide range of drugs are administered through the oral route. When compared with conventional dosage form FDT can be a useful alternative as well. FDT’s are advantageous particularly for paediatric, geriatric and mentally ill patients who have difficulty in swallowing conventional tablets and capsules. Fast dissolving tablet (FDT) is one type of an innovative, unique drug delivery system and the field has become a fast-growing area in the pharmaceutical industry. Fast dissolving Tablets are disintegrated or dissolved rapidly with the saliva. Some tablets are designed to dissolve in saliva usually fast, within a few seconds, and are true fast-dissolving tablets. Disintegrants are substances or combination of substances added to a drug formulation to aid in the breaking up or disintegration of tablet or capsule content into smaller fragments that dissolve more quickly. Several newer agents of disintegrants known as ‘Super-disintegrants’. Super disintegrants are classified as natural, synthetic, semi-synthetic, and co-processed blends have been used to create effective mouth dissolving tablets and overcome the limitations of traditional tablet dosage form. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. This review article contains different techniques used for preparing FDT, sailent features, various patented technologies, mechanism of super disintegration, evaluation tests, challenges faced and the limitations.

Keywords: Fast disintegrating tablets, Disintegrants, Bioavailability, Sublimation, Freeze Drying, Moulding, Fast Dissolving Film.