Abstract

PULSATILE DRUG DELIVERY SYSTEMS - A REVIEW

P. S. S. Prasanna Kumar*, T. Anjali, Srinivas Nandyala, P. Vanitha, T. Srihitha, M. Yamini Saraswathi, S. K. Dilshad, K. Madhuri and N. Nikitha

.

Abstract

The pulsatile drug delivery system has carried off a lot of importance in drug delivery technology in the last 30 years. In this type of drug delivery systems, the devices deliver the right dose, at a specific location at a particular time in the field of pharmaceutical industry. Under this pulsatile drug delivery system, some conditions show positive result. It includes duodenal ulcer, cardiovascular disease, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension, and hypercholesterolemia. For chronopharmaceutical drug delivery some technologies such as time-controlled, pulsed, triggered and programmed drug delivery devices have been developed and extensively studied in recent years. When compared to conventional dosage form this system has more multiple benefits. These pulsatile drug delivery systems gaining more importance in the field of pharmaceutical technology. Recent trends comprise multi particulate drug delivery systems which are especially suitable for attaining controlled release oral formulations with a property of dose dumping and flexibility to attain different release patterns as well as reproducible and short gastric residence time. There are different methods and different marketed technologies are available for pulsatile drug delivery systems like Pulsincap TM, Diffucap, CODAS, OROS etc.

Keywords: Pulsincap TM, Diffucap, CODAS, OROS etc.