Abstract

FLOATING DRUG DELIVERY SYSTEMS - A REVIEW

P SS Prasanna Kumar*, T. Anjali, Srinivas Nandyala, K. Sravani, P. Ratnam, P. Durgadevi, A. Umadevi, K. D. Sai Kumar and G. S. Manikanta

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Abstract

Floating drug delivery systems (FDDS) mainly depends on the principle of floatation. The recent developments of FDDS including physicochemical properties and mechanism are explained in detail. When compared with the other conventional dosage forms, floating drug delivery system shows effective therapeutic activities. The different methodologies such as effervescent and non-effervescent systems are introduced based on the parameter density. The novel methodologies in FDDS includes such as single dose and multi dosing system. This review also involves in giving information about in-vitro and in-vivo dissolution studies. Floating dosage forms can be delivered in conventional forms like tablets, capsules with the addition of suitable ingredients along with the gas generating agent. Floating drug delivery system improves the drug bio-availability and patient compliance by enhancing the gastric retention time and controlling drug release. In recent years there are several technologies were to develop to overcome the barriers like short gastric retention time and unpredictable gastric emptying time. In this review, we discussed about novel technologies and developments regarding floating drug delivery system.

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