Abstract

A REVIEW ON SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM

Gayatri B. Savakar*, Pallavi A. Harde, S. B. Gondkar and R. S. Bachhav

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Abstract

Self-emulsifying drug delivery system is categorised on factors such as size of droplets acquired after dispersion. Self-Micro Emulsifying Drug Delivery Systems (SMEDDS) are defined as having a droplet size of dispersion between 100 and 250 nm, whilst Self Nano Emulsifying Drug Delivery Systems have a droplet size below 100 nm. SNEDDS are isotropic mixtures of natural or synthetic oils, surfactants, and cosurfactants that have the unique ability to form fine oil in water (O/W) nano-emulsions of approximately less than 100 nm upon dilution with water upon mild agitation. A SNEDDS formulation can be optimised through a phase diagram approach or statistical design of experiment. SNEDDS improve the oral bioavailability of hydrophobic drugs by several mechanisms. The self-emulsification time, dispersibility study, average globule size, and Poly dispersibility index (PDI) of the produced formulation were all examined. The globule size of the optimised system will be less than 100 nm, which could be an acceptable nano emulsion range.

Keywords: Self nano emulsifying DDS, oil, surfactants, statistical design of experiment, Poly dispersibility index, bioavailability.