Abstract

PHYTOCHEMICAL SCREENING AND INVITRO ANTHELMINTIC ACTIVITY OF METHANOLIC EXTRACT OF ALLIUM CEPA BULBS

L. Krishnaveni*, Dr. T. Satyanarayana, A. Jitendra Nayak, S. Sukanya, M. Siva Ram Chandu, P. Sravani, T. Navya Sri

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Abstract

Development of anthelmintic resistance and high cost of conventional anthelmintic drugs lead to the evaluation of medicinal plants as a alternative source of anthelmintics. In the present study, the bulbs of Allium Cepa were successively extracted with maceration using methanol as a solvent. The aim of the present study was to perform the phytochemical screening and to evaluate the anthelmintic activity of methanolic extract of bulbs of Allium Cepa belonging to the family Amaryllidaceae. The anthelmintic activity was analyzed by methanolic extract of different concentrations-25, 50, 100mg/ml by using Indian adult earthworm, Pheretima posthuma having anatomical and physiological resemblance with intestinal worms. The time of paralysis and time of death were studied and the activity was compared with Piperazine citrate as a standad reference. We demonstrated that, the results supported the traditional use of Allium Cepa in the treatment of Helminthiasis.

Keywords: Allium Cepa bulbs, phytochemical screening, pheretima posthuma, piperazine citrate.