Abstract

CHRONIC FATIGUE SYNDROME: A REVIEW

Anusha, Suraj Sharma Ramica Sharma*

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Abstract

Myalgic encephalomyelitis also known as chronic fatigue syndrome (ME/CFS) is a group of diseases that affects millions of individuals throughout the world and is basically characterized by debilitating tiredness that lasts for 6 months. The precise mechanism of the pathophysiology of ME/CFS has yet to be discovered however various studies indicate that cytokines, immunoglobulins, T and B cells, Natural killer cells (NK cells), viral infection, and diminished hypothalamic-pituitary-adrenal axis response are involved in it. Currently, no particular pharmacological treatment is available in the market for the management of ME/CFS. If available they provide only symptomatic relief. Thus, the purpose of this review is to explicate different pathophysiological approaches to understanding the paramount concepts of ME/CFS and open the vista for pharmacological treatments that aid in better treatment beneficial in ME/CFS.

Keywords: Cytokines, Natural killer cells, T and B cells, ME/CFS.