Abstract

A REVIEW ON HYDROTROPY: A SOLUBILITY ENHANCING TECHNIQUE

Akash Haribhau Thengade*, Rajeshwari K. Thokal and Gajanan S. Sanap

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Abstract

The methodology employed to increase solubility using hydrotropy technique is the foundation of the current review. A drug's bioavailability and solubility are key factors in its efficacy. Drug solubility is crucial for systemic drug concentration and the demonstration of pharmacological response. Currently, just 8% of new drugs have both high and low effects. Solubility and Permeability, yet due to low bioavailability, more than 40% of lipophilic drugs never make it to market. A high dose is necessary to achieve the right pharmacological activity before a lipophilic medication can be sold. At this time, hydrotropic solution having significant industrial demand as a result of their special qualities, such as simple availability, rapid recovery, lack of fire risks, etc. One method for increasing solubility is hydrotropy, which uses hydrotropes including urea, sodium benzoate, and sodium citrate. The term "hydrotropy" refers to a certain method of solubilization that increases a solute's solubility in water by adding a significant amount of a second solution.

Keywords: Hydrotropy, Bioavailability, Permeability, Solubility, Lipophilic drug.