Abstract

ENHANCEMENT OF DISSOLUTION RATE OF LERCANIDINE BY SOLID DISPERSION TECHNIQUE

Chinchawade Ashlesha B* and Gadhave Manoj V

Abstract

Solubility is an important physicochemical factor affecting absorption of drug and its therapeutic effectiveness. Consequences of poor aqueous solubility would lead to failure in formulation development. The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. In the present investigation, an attempt were made to improve the solubility and dissolution rate of a poorly soluble drug, Lercanidipine by solid dispersion (Spray drying) method using polyvinyl pyrrolidone K‐30, β‐cyclodextrin as carrier. Solid dispersion of Lercanidipine was prepared by spray drying method. In vitro release profiles of all Solid dispersions were comparatively evaluated and also studied against pure Lercanidipine. Faster dissolution was exhibited by F6, Solid dispersion containing 1:3 ratio of drug: PVP K30 by Spray drying method. The prepared Solid dispersions were subjected for percent practical yield, drug content, infra red (IR) spectroscopic studies and differential scanning calorimetry (DSC). FT‐IR spectra revealed no chemical incompatibility between drug and β‐cyclodextrin. Drug ‐ polymer interaction were investigated using differential scanning calorimetry (DSC).

Keywords: Lercanidipine, Solid dispersion, PVP K?30, ??cyclodextrin.