Abstract

A REVIEW ARTICLE ON A NOVEL AND TARGETED DRUG DELIVERY SYSTEM IN FORM OF LIPOSOMES

Satendra Kumar* and Anil Kumar

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Abstract

In this review article, we discussed about liposome, these are one amongst the various drug delivery system used to target the drug to particular tissue. Because of structure similarity between lipid bilayers & cell membrane Liposome is a spherical sac Phospho lipid molecule. Liposomes are a novel drug delivery system (NDDS), The term liposome means lipid body. It has been derived on the basis of name of sub cellular particles, ribosome. Liposomes were first made by A.D Bangham in early 1960s. Their size ranges from 25 to 500nm.It encloses a water droplet especially as form artificially to carry drug into tissue membrane. It is spherical sac vesicle it consists at least one lipid bilayers. The process of sonication (extrusion) is required to obtain small size and narrow size distribution of liposome. They are simple microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers. Novel drug delivery system aims to deliver the drug at a rate directed by the needs of the body during the period of treatment, and channel the active entity to the site of action. Liposomes are colloidal spheres of cholesterol non-toxic surfactants, sphingolipids, glycolipids, long chain fatty acids and even membrane proteins and drug molecules It is differ in size, composition and charge. Consequently a number of vesicular drug delivery systems such as liposomes, niosomes, transfer some, and Pharma cosmos were developed. It is a drug carrier loaded with great variety of molecules such as small drug molecules, proteins, nucleotides and even plasmids. Few drugs are also formulated as liposomes to improve their therapeutic index. The main significant role in formulating of potent drug, improve therapeutic effect.

Keywords: Drug delivery system using components of liposomes, Method of preparation of liposomes Structural components of liposomes, Vesicles, Colloidal spheres.