Abstract

ALZHEIMER’S DISEASE AND ITS EFFECTIVE PHARMACOLOGICAL MANAGEMENT

Pallavi Bangar*, Payal Pilaji, Shubham Wakode, Rakesh Nayak, Aditi Rambade

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Abstract

Dementia caused by Alzheimer's disease (AD) is characterized by a specific neuropathology and onset and progression of cognitive and functional impairment that is age-related. Alois Alzheimer initially discussed the patient he first saw in 1901 in his description of him in 1906. Neurodegenerative disorders are brought on by intracellular Amyloid plaques, neurofibrillary tangles, and extracellular amyloid protein depositions. Generally three hypotheses were proposed such as Tau hypotheses, Cholinergic hypothesis and Amyloid hypothesis which makes Alzheimer’s an multifactorial diseases. The condition is also influenced by a number of risk factors, including increased age, infections, brain trauma, and vascular disease. However, to combat it, several medications have been approved, such as cholinesterase enzyme inhibitors and N-methyl D-aspartate (NMDA) antagonists, which have a major influence on treating symptoms but are unable to treat AD.

Keywords: Alzheimer’s Diseases, Tau Hypothesis, Neurofibrillary tangles, Acetylcholinesterase, Galantamine, Memantine.