Abstract

CHRONOPHARMACOLOGY AND TREATMENT OF CANCER THROUGH CHRONOTHERAPY

Pallavi Bangar*, Yogendra Salunke, Sangram Shewale, Rupali Vanve and Suraj Pawar

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Abstract

All living things, including humans, undergo regular changes in their physiological, biochemical, and behavioural states. These variations prioritize specific bodily activities at specific times of the day while conserving energy at other times in order to maximize energy utilization. The central and peripheral circadian clocks regulate circadian rhythm in response to zeitgebers like food and sunlight. Chronopharmacology is the study of how medications are influenced by biological rhythms. It aims to improve drug therapy by choosing the right moment to provide pharmaceuticals for optimum effectiveness and fewest side effects. Cancer chronotherapy seeks to enhance the tolerance and effectiveness of anticancer medications by administering them in accordance with circadian rhythms. Nevertheless, research on mice and human subjects demonstrates that lifestyle factors such as sex, genetics, pharmaceuticals, and cancer may alter the dynamics of the host's metabolic pathways and circadian clocks, affecting when it is best to provide medications. In fact, the mathematical modelling of chronopharmacology may help to modify the ideal time in light of patientspecific factors. Irinotecan is a topoisomerase I inhibitor with a complicated metabolism and a history of effectiveness against colorectal cancer. Here, we use in vitro and in silico approaches to define the key molecular pathways that control the chronopharmacology of irinotecan. According to in vitro circadian medication timing, these molecular rhythms translated into statistically significant alterations in pharmacokinetics and pharmacodynamics. According to the time of the medication, the top-up of the several coordinated chronopharmacology pathways caused a four-fold variation in irinotecan-induced apoptosis. Cancer and other diseases have been linked to circadian abnormalities.

Keywords: Chronopharmacology, Chronopathology, Chronophysiology, Chronopharmacokinetics, Chronoesthesy, Chrono-Pharmacotherpy, Biological Rhythm, Cancer.