Abstract

A REVIEW ON FORMULATION OF SUSTAINED RELEASE PELLETS BY DIFFERENT TECHNIQUES

Tanvi Vilasrao Deshmukh*, Ankita P. Kawtikwar and P. S. Kawtikwar

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Abstract

The best and fastest choice for administering different medications is oral drug delivery because it has the largest active surface area of any drug delivery system. Sustained release drug delivery has several benefits over traditional dosage forms such as increased patient compliance due to less frequent drug administration, maximum drug consumption, increased safety margin of potent drug, reduction of fluctuation in steady-state drug levels, reduction in healthcare costs due to better therapy, and shorter treatment period. The improvement of drug therapy is the primary objective of sustained release forms, which is determined by the connection between the benefits and drawbacks of sustained release system. By avoiding fluctuations in the therapeutic concentration of the drug in the body, sustained release is another hopeful method for reducing side effects. The therapeutic impact and safety of a drug will be optimised by the sustained release product, while patient convenience and compliance are also improved. According to recent trends, multiparticulate drug delivery systems are particularly well suited for producing extended release oral formulations with low dose dumping risk, flexibility in blending to achieve various release patterns, and repeatable and brief gastric residence times. The quantity of drug contained in pellets as well as the carrier used to create them are among the variables that affect how quickly the drug is released from them. Pellets thus greatly expand the potential for developing novel controlled and prolonged release oral formulations, thereby advancing pharmaceutical research. Micrometric characteristics, surface morphology, drug concentration, in-vitro drug release, and a dissolution kinetic model were all assessed for the pellets.

Keywords: Pelletization, Extrusion Spheronization, Sustained Release Pellets, Powder Layering, Melt Extrusion.