Abstract

EVALUATION OF ANTIBACTERIAL ACTIVITY OF CISSUS QUADRANGULARIS AGAINST NASOCOMIAL INFECTANTS

Prabhavathi, Jayaramu.M and Prasad.M.P*

Abstract

Cissus quadrangularis Linn is one of the medicinal plants which are found in India and this plant belongs to the family Vitaceae. In this present study, a comparative evaluation of the antimicrobial activity of the leaf, root, fruit and stem extracts of Cissus quadrangularis eluted using different solvents like chloroform, diethyl ether and petroleum ether were carried out. The nasocomial pathogens were isolated fromclinical specimens from the hospital patients. The Chloroform extract of the samples showed antimicrobial activity against most of the clinically isolated pathogenic microorganism. Diethyl ether extract of the samples showed antimicrobial activity against only few of the microorganisms. The stem extracts from all the solvent showed antagonistic effect against P.aeruginosa. The chloroform extracts of the leaf sample showed a better antimicrobial effect against the microorganisms whereas the Diethyl ether extract showed antimicrobial effect against only Entero bacteraciea. Petroleum ether extract of the leaves did not show any antimicrobial activity. The Chloroform extract of the Root sample showed antimicrobial activity against five microorganisms, whereas the Diethylether extract showed activity against only 2 microorganisms. The Chloroform extract from the Fruit samples showed a prominent antimicrobial activity against only five microorganisms. The minimum inhibitory concentration was analysed for the Chloroform samples as most the solvent extract showed higher zone of inhibition. The MIC for most of the samples was found to be at 40μg except for Enterobactericeae against Root sample. The present study indicates the potential of Cissus quadrangularis as a source with medicinal applications.

Keywords: Cissus quadrangularis, Medicinal plant, Antagonistic, clinical isolates, Chloroform.