EVALUATION OF ANTIBACTERIAL ACTIVITY OF CISSUS QUADRANGULARIS AGAINST NASOCOMIAL INFECTANTS
Prabhavathi, Jayaramu.M and Prasad.M.P*
Abstract
Cissus quadrangularis Linn is one of the medicinal plants which are
found in India and this plant belongs to the family Vitaceae. In this
present study, a comparative evaluation of the antimicrobial activity of
the leaf, root, fruit and stem extracts of Cissus quadrangularis eluted
using different solvents like chloroform, diethyl ether and petroleum
ether were carried out. The nasocomial pathogens were isolated
fromclinical specimens from the hospital patients. The Chloroform
extract of the samples showed antimicrobial activity against most of
the clinically isolated pathogenic microorganism. Diethyl ether extract
of the samples showed antimicrobial activity against only few of the
microorganisms. The stem extracts from all the solvent showed
antagonistic effect against P.aeruginosa. The chloroform extracts of
the leaf sample showed a better antimicrobial effect against the microorganisms whereas the
Diethyl ether extract showed antimicrobial effect against only Entero bacteraciea. Petroleum
ether extract of the leaves did not show any antimicrobial activity. The Chloroform extract of
the Root sample showed antimicrobial activity against five microorganisms, whereas the
Diethylether extract showed activity against only 2 microorganisms. The Chloroform extract
from the Fruit samples showed a prominent antimicrobial activity against only five
microorganisms. The minimum inhibitory concentration was analysed for the Chloroform
samples as most the solvent extract showed higher zone of inhibition. The MIC for most of
the samples was found to be at 40μg except for Enterobactericeae against Root sample. The
present study indicates the potential of Cissus quadrangularis as a source with medicinal
applications.
Keywords: Cissus quadrangularis, Medicinal plant, Antagonistic, clinical isolates, Chloroform.
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