Abstract

AN ACUTE ORAL TOXICITY STUDY ALONG WITH HEAVY METAL ANALYSIS OF A SIDDHA FORMULATION MANJANAATHI KUDINEER

Haripriya M.* and Tamilselvan R.

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Abstract

Manjanaathi Kudineer (MKR) an herbal formulation of Siddha medicine, which is prescribed for Neerkana Maantham (Acute nasopharyngitis) in Children. To evaluate its safety, acute oral toxicity study was performed following OECD test guidelines 423. MKR was administered orally at 5, 50, 300 and 2000 mg/kg body weight. Animals were observed for toxic signs for 14 days. There were no significant behavioral changes and also in body weight, water intake, food intake. There is no treatment related death or toxic signs were observed. Heavy Metal Analysis was done by Atomic Absorption Spectrometry (AAS) Model AA 240 Series. Which shows there is no traces of heavy metals. This study provides scientific validation for the safety of MKR.

Keywords: Siddha, Manjanaathi Kudineer, Acute Oral Toxicity, Neerkana Maantham.