Abstract

DESIGNED A BIOACTIVE SYNTHESIS OF SCHIFF BASE CONTAINING ETHYL 2- AMINO BENZOATE MOIETY PROMOTED BY BRONSTED ACID

P. Ramesh, J. Prudhvi Raj, B. Priyanka and N. Krishnarao*

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Abstract

The objective of this study was to investigate the bioactivity of an improved method of process for the synthesis for series of novel Schiff bases from ethyl 2-aminobenzoate with substituted aromatic aldehydes using methane sulfonic acid in free solvent at room temperature. The intermediate moiety ethyl 2-aminobenzoate can be synthesized from 2- aminobenaoic acid and ethanol small amount of concentrated sulphuric acid which is obtained from pthalic anhydride with sodium hypo bromide. All the newly synthesized derivatives were evaluated by the advanced spectroscopic data (IR, 1H-NMR, 13C-NMR and LC-MS) and also structural determination were calculated by elemental analysis. Besides to all compounds were screened by their biological activities.

Keywords: Ethyl 2-aminobenzoate, methane sulfonic acid, Methane sulfonic acid, Schiff bases, Bioevluation.