Abstract

DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF A NOVEL SERIES OF OXAZOLONES PROMOTED BY K3PO4 AS CATALYST

B. Rambabu, B. Priyanka and Dr. N. Krishna Rao*

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Abstract

The synthetic pathways and in-depth antimicrobial study a series of six 4-((E)-benzylidene)-2-((E)-styryl) oxazol-5(4H)-one (5). These moieties were obtained by condensation of substituted aromatic aldehydes (4) and cinnamoylglycine (3) with acetic anhydride in the presence K3PO4 as a catalyst. The compound (3) was prepared from cinnamoylchloride (2) with glycine and cinnamoylchloride (2) can be obtained from cinnamic acid and thionylchloride in the presence of MDC at 5-100C. All the eight evaluated by advanced spectral data (1HNMR, 13CNMR & LCMS) and the structure of the all titled derivatives can be determined by elemental analysis. In addition to evaluation of ant-microbial properties against four bacterial strains as well as two fungal strains.

Keywords: Cinnamoylglycine, substituted aromatic aldehydes, K3PO4, 4-((E)- benzylidene)-2-((E)-styryl) oxazol-5(4H)-one.