Abstract

SYNTHESIS, CHARACTERISATION AND BIOLOGICAL EVALUATION OF SOME ETHOXYPHTHALIMIDE DERIVATIVES OF THIADIAZOLE AND QUINAZOLINE

R. R. Dangi* and N.S. Chundawat

Abstract

Thiosemicarbazide of isoniazide (2) was used as a starting material for the synthesis of N-ethoxyphthalimido- 3-[5-(pyridin-4-yl)-1, 3, 4- thiadiazol-2-yl] quinazoline-2, 4(1H,3H)-dione (5). Isonicotinoylthiosemicarbazide (2) was treated with conc. H2SO4/NH3 to get 5-pyridin-4-yl-1,3,4-thiadiazol-2-amine (3) which gave 3-[5- (pyridin-4-yl)-1,3,4-thiadiazol-2-yl]quinazoline-2,4(1H,3H)-dione (4) corresponding isatoic anhydride moiety. Compounds 4 were converted to targeted molecules (5) by the base induced condensation with bromoethoxyphthalimide. Structures of all the synthesized compounds have been confirmed on the basis of physical parameters, chemical tests and spectral studies. Final compounds were screened for Antimicrobial activity.

Keywords: Isoniazide, Thiadiazole, ?-bromoalkoxyphthalimide, Antimicrobial activity.