Abstract

A THERAPEUTIC APPROACH TOWARDS PAINFUL AND IRREGULAR MENSES IN RELATION TO PROSTAGLANDINS

Pathak Meenakshi S.N*, Awadhesh Pandey, Randhir kumar, Prof. Manjari Dwivedi, Prof. P.L Pakrasi

Abstract

The quality of life of adolescents and young adult women are commonly affected by menstrual disorders. Among them painful menses comprises of 87.7% of Indian females of reproductive age group. It has a negative effect on a woman‟s life. The woman may confine to bed due to severe pain. It refers to the occurrence of painful menstrual cramps of uterine origin. This gynaecological condition has considerable morbidity. The aim of the study is to alleviate the pain during menses by Ayurvedic Therapy which will impart easy, effective and less side effect producing care and can be easily administered on proper counselling and well accepted by the patient. A study was conducted in 75 females of reproductive age group, diagnosed with painful and irregular menses. Patients data were collected by direct history and from the old medical records of the patients, the prescriptions about different modern medical treatment taken for their disease and considering them the patients were registered. To have the idea of complete efficacy, 3 groups were taken for study. A group of oral Guduchyadi Vati, another group of Guduchyadi taila Uttar Basti (i.e Intra uterine instillation) and third as a combined one with both oral and intra uterine instillation. In above three group an experimental analysis was done by assessment of Endometrial Prostaglandins (causative agent of pain) before and after treatment through Histopathology and Immunohistochemistry with COX 2 antibody so as to see the exact effect of drug on Prostaglandins. The Experimental study on Histology of Endometrium showed the decrease in inflammatory markers before and after treatment but there was significant decrease in markers in group III (oral tablet and intrauterine oil instillation), moderate in group II (only intrauterine oil instillation) and least in group I only oral tablets). In Immunohistochemistry of endometrium before and after treatment, there was significant decrease in COX 2 expression in Group III patients followed by group II and then in group I.

Keywords: painful, irregular menses, endometrium, prostaglandins, COX-2, Ayurveda.