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Abstract

FORMULATION AND EVALUATION OF NIZATIDINE FAST DISSOLVING TABLETS.

Balagani Pavan Kumar*, G.Archana, Yaddalapudi Swarupa, and Katamreddy Jyothshna Devi.

Abstract

Nizatidine is a H2 receptor antagonist used to treat gastric andduodenal ulcers and gastroesophogeal reflux disease. Fast dissolvingtablets of Nizatidine offer the advantage of convenience ofadministration during travelling and patient compliance. The presentstudy aims to formulate and evaluate fast dissolving tablets (FDT’s) ofNizatidine with acceptable taste and minimum disintegration time. Thesolid dispersions of drug with Eudragit E100 which has both tastemasking and super disintegrant properties were prepared by solventevaporation method and spray drying method. The drug, polymersand physical mixtures are subjected for compatibility studies usingFTIR and DSC studies. Fast dissolving tablets were prepared bydirect compression method using prepared solid dispersionsand superdisintegrants Crospovidone, Croscarmellose sodium andSoy polysaccharide in various concentrations (6%, 10% and 15%). The tablets wereevaluated for hardness, wetting time, friability, disintegration time and in-vitro dissolution.The disintegration time and wetting time of the prepared tablets was found to be in the range8.40±0.369 to 87.13±0.364sec and 6.79±1.712 to 32.46±2.488 sec. respectively. Thedissolution release rates after 10min.were found to be in the range 31.51±0.74 to68.69±0.65 for all the formulations. The formulation containing solid dispersion of drugprepared by solvent evaporation and 15% polyplasdone was found to give the best resultswith disintegration time of 8.40±0.369 sec.

Keywords: Nizatidine; Fast dissolving tablets; Eudragit E100; Solvent evaporation; Spray drying; Superdisintegrants.


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