Abstract

A NEW APPROACH TO THE SYNTHESIS OF 4-THIAZOLIDINONE USING DCC AS CATALYST AND TO STUDY THEIR ANTIMICROBIAL ACTIVITIES

Gajanan G. Kadam, Rameshwar M. More and Subhash B. Junne*

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Abstract

Interesting scaffold 2,3-disubstituted 4-Thiazolidinone has been synthesized by three component reaction between substituted 1,3- disubstitued pyrazole- 4-carbaldehyde, Heterocyclic Amines and Thiogycolic acid using DCC as a catalyst the reaction is monitored on TLC plate, these synthesized compounds conformed on the basis of spectral analysis such as IR, NMR and Mass spectroscopy. These newly synthesized compounds show good to moderate microbial activities as compared with standard drug.

Keywords: 4-Thiazolidinone, 1,3-disubstitued pyrazole- 4- carbaldehyde, Thiogycolic acid, DCC.