Abstract

ANTIMICROBIAL ACTIVITIES OF LIGANDS AND ITS METAL COMPLEXES

Mallikarjun Kote*

Abstract

Synthetic Schiff base ligands and their complexes are known to possess appreciable antibacterial activity. The characteristic property has been related to the ability of the metal ion form complexes with ligands containing nitrogen oxygen donor atoms. A comparative study of the ligand and their metal complexes indicate that most of the metals chelate exhibit higher biological activity than that of the free ligand. The increase antifungal activity of the metal chelate with increase in concentration is due to the effect of metal ion on the normal cell process. Such increased activity of the metal chelate can be explained on the basis of overtone’s concept and chelating theory.

Keywords: Cup-plate method, microbial activity, chelate.